695 results found
Novel approaches to early detection and treatment of ASD
Project Overview
More than 1 in 100 individuals are diagnosed with Autism Spectrum Disorder (ASD), with profound impacts on the quality of life of those who are affected and their families. Until recently, children were rarely referred for assessment before age 2, so we knew little about ASD early in life. Prior…
Project Complete
See the project and researchersTesting therapeutic approaches to improve cognitive dysfunction in a primate model of Alzheimer’s Disease
Project Overview
Alzheimer’s Disease (AD) is a severe dementia that is likely a result of years of buildup in the brain of molecules called amyloid-beta oligomers (AβOs). The pursuit of new disease-modifying therapeutics for AD that change the natural progression of AD early in its course is under intense investigation. A major…
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See the project and researchersNovel approaches to understand the role of cAMP and co-signaling cascades in synaptic plasticity and brain disorders
Project Overview
Synaptic plasticity is the process where the strength of connections between nerve cells is altered by experience. It is widely believed that synaptic plasticity is used to store information in the brain and is important for learning and memory and other major cognitive processes. The most widely studied form of…
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See the project and researchersCognitive Outcomes and Response/Remission Efficacy of Convulsive Therapies in Treatment Resistant Depression: The CORRECT-TRD Trial
Project Overview
Magnetic Seizure Therapy (MST) is a novel form of treatment that uses high intensity magnetic field pulses to stimulate the brain and induce a seizure as a therapeutic intervention for patients with depression resistant to antidepressant medication, known as Treatment Resistant Depression (TRD). Preliminary research has shown that MST is…
Project Ongoing
See the project and researchersThe Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions
Project Overview
One of the most important questions of biomedical research is “why do we ail as we age?”. This may be in part due to a breakdown of the body’s circadian rhythm - the physiological process that tunes up or down various bodily functions during the 24 hr cycle. Another aspect…