695 results found
Reshaping Mitochondrial Efficiency and Integrity to Treat Parkinson’s Disease
Project Overview
Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. This movement disorder is thought to be due to the loss of a specific population of nerve cells, the dopamine (DA)-containing neurons located in the substantia nigra pars compacta (SNc). The question as to why this…
Project Complete
See the project and researchersNovel blood and neuroimaging markers of Alzheimer’s disease and cerebral amyloid angiopathy
Project Overview
As our brains age, they become vulnerable to diseases such as Alzheimer’s disease which can cause dementia. Dementia is defined as cognitive (i.e., thinking) problems that interfere with usual daily activities. In the milder stages of dementia, this includes difficulty with shopping, finances, and cooking. As dementia progresses, difficulties with…
Project Complete
See the project and researchersCombining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?
Project Overview
A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke. This has a tremendous impact on the quality of life and the ability for stroke survivors to live independently. While exercise is considered essential to any rehabilitation program, its benefits are generally…
Project Ongoing
See the project and researchersMontreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants
Project Overview
Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ. This suggests that many different mechanisms are causing these disorders in patients. This great diversity has hindered…
Project Ongoing
See the project and researchersPreclinical development of a disease modifying small molecule therapy for Alzheimer disease
Project Overview
No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches need to be quickly pursued in order to develop useful treatments for the aging population. The two pathological hallmarks of AD are protein…