695 results found
Validation of Connexins and Pannexins as a target for Alzheimer’s Disease
Project Overview
Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today,…
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See the project and researchersModulating memory circuits: focal DBS treatments to improve medial temporal lobe function
Project Overview
Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The diseases in question are Alzheimer’s disease, a devastating neurodegenerative disorder, and temporal lobe epilepsy, the most common type of partial-seizure epilepsy, characterized by brief episodes of abnormally synchronous neural activity.…
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See the project and researchersBiomarkers for Crossing the Translational Divide in Acute Spinal Cord Injury
Project Overview
Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Unfortunately, none of the promising treatments that have emerged from animal models of SCI have demonstrated convincing neurologic…
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See the project and researchersAdolescent Mental Health
Project Overview
Most mental disorders begin in adolescence; however, there are many gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop an illness, what that illness will…
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See the project and researchersTargeting the Synaptic Pathway in Neurodevelopmental and Psychiatric Disorders
Project Overview
Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social interaction, poor communication, and restricted, stereotyped patterns of behavior. Autism and schizophrenia affect over 1% of the population, and each has strong genetic associations with 60-90% heritability among twins. Recent research identified mutations in a shared genetic pathway in…