720 results found
ShARP: Screenable assays for RNA-binding proteins involved in brain disorders and diseases
Project Overview
Brain disorders such as autism, major depressive disorder and Alzheimer’s disease are among the greatest medical challenges of our era. Many drugs targeting the central nervous system (CNS) have been developed to modulate G protein-coupled receptors, ion channels or transporters with mitigated success. There remains a shortage of disease-relevant targets…
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See the project and researchersA Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Project Overview
Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65. However, a major hindrance in developing therapies for disorders of the brain has been limited access to human neurons from…
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See the project and researchersNon Invasive Identification of Aβ Plaques in Human Retina for the Diagnosis of Alzheimer’s Disease
Project Overview
Currently, AD diagnosis can only be confirmed post-mortem by observing two AD hallmarks in the brain, β-amyloid (Aβ) plaques and tau strands. Diagnosing AD earlier in its course could dramatically transform the design of clinical trials to test new treatments. A team of researchers led by Dr. Jean-Paul Soucy of…
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See the project and researchersSolid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies
Project Overview
This project proposes to integrate the low-invasive, non-lethal in vivo sampling/sample preparation SPME approach with MS detection to obtain the full profile of brain metabolome and lipidome, the quantification of drugs and monitoring of their metabolism, selective extraction of target compounds (drugs or selected endogenous metabolite), as well as high…
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See the project and researchersDrug Delivery across the Human Blood-Brain Barrier
Project Overview
Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Abnormal clusters of protein fragments build up between nerve cells in the brainleading to impaired memory. The most important therapies in development currently are biologics, antibodies and peptides that bind and neutralize toxic…