687 results found
Synergistic combination of IAP antagonism and immunotherapy to treat brain cancers
Project Overview
Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr Robert Korneluk has found that combining IAP-blocking drugs with immunotherapy can kill cancer cells very effectively. Dr Korneluk will now…
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See the project and researchersDeciphering eEF2K biological functions for therapeutic targeting of neural tumours
Project Overview
In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He…
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See the project and researchersOncolytic rhabdovirus immunotherapy for brain cancer
Project Overview
Dr David Stojdl's lab has custom‑built an oncolytic virus biotherapy specifically for the treatment of the devastating brain cancer, glioblastoma multiforme (GBM). Maraba‑LG kills brain cancer cells but leaves normal healthy tissue intact, and is one of the only oncolytic viruses in the world that can be safely injected at…
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See the project and researchersTargeting the telomere maintenance pathway for cancer diagnostics and therapeutics.
Project Overview
Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Dr. Uri Tabori is a world expert in telomeres – the protective caps at the ends of DNA. Dr. Tabori has discovered that telomeres are maintained by a section of DNA called THOR. THOR…
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See the project and researchersMolecular heterogeneity drives the clinical behaviour of childhood medulloblastoma
Project Overview
Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain cancer of childhood. Children diagnosed with medulloblastoma are often left with long-term effects from the intensive treatment. Dr. Taylor is studying how different medulloblastomas vary one from another…