740 results found
Tracking Alzheimer’s disease progression at the earliest stages: a multimodal project
Project Overview
New neuroimaging techniques enable us to measure the key hallmarks of Alzheimer's disease (AD) pathology before symptoms appear. The AD pathologic process is known to begin decades before the appearance of dementia symptoms such as memory or language deficits. Therefore, Dr. Villeneuve will use these new imaging methods alongside existing…
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See the project and researchersThe interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease
Project Overview
Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Enhancers are elements in the DNA code that enable the complex expression of genes. Epigenetic marks control enhancers, which in turn creates specific…
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See the project and researchersNovel Cellular and Molecular Mechanisms Regulating Synapse Dysfunction in Alzheimer’s Disease
Project Overview
In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment called AÎ that disrupt synapse function and cause neuronal death. Dr. Kennedy and his team will study a protein called netrin-1 that promotes cell…
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See the project and researchersStrains of A-beta aggregates in Alzheimer’s disease
Project Overview
The existence of different strains of misshapen proteins in the brains of Alzheimer’s disease (AD) patients is emerging as an obstacle to the development of effective treatments. Recent research has revealed that the proteins that accumulate in the brain during AD are reminiscent of prions, which cause rare brain diseases…
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See the project and researchersDevelopment and validation of reagent kits for commercial high-throughput screening of PPI s and PPI inhibitors
Project Overview
Membrane proteins are biological molecules of incredible importance, playing diverse roles in many processes critical to life. Improper function of membrane proteins, however, is associated with many different diseases, such as diabetes, neurological disorders and cardiovascular diseases (among others). Membrane proteins are therefore of great therapeutic interest, and in fact…