687 results found
Novel Retinal Biomarkers for Alzheimer’s Disease
Project Overview
Individuals with Alzheimer’s suffer severe memory loss over time, and eventually are completely dependent on caregivers. Age is a significant risk factor, and the longer we live, the higher the chances of getting Alzheimer’s. Detecting the beginning of Alzheimer’s in an individual’s brain in the early stages is difficult as…
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See the project and researchersTargeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology
Project Overview
A treatment or prevention of Alzheimer's disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. However, there are many different subtypes of amyloid-beta oligomers and the specific…
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See the project and researchersLocally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question
Project Overview
One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly understood at the level required…
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See the project and researchersDistinct neuro-immune interactions drive sex differences in chronic pain
Project Overview
One of the most important advances in our understanding of chronic pain over the last decade or so is the realization that neurons are not the only cells in the central nervous system participating in the processing of pain signals. Immune-like "glial" cells (especially microglia and astrocytes), thought previously to…
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See the project and researchersNeurobiological correlates of TMS
Project Overview
Noninvasive brain stimulation is gaining acceptance as an alternate therapy for an increasing number of disorders, including major depression, schizophrenia, stroke and Parkinson’s disease. A form of noninvasive brain stimulation called transcranial magnetic stimulation (TMS) is less invasive and safer as compared to other brain stimulation therapies; however, lack of…