695 results found
Locally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question
Project Overview
One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly understood at the level required…
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See the project and researchersDistinct neuro-immune interactions drive sex differences in chronic pain
Project Overview
One of the most important advances in our understanding of chronic pain over the last decade or so is the realization that neurons are not the only cells in the central nervous system participating in the processing of pain signals. Immune-like "glial" cells (especially microglia and astrocytes), thought previously to…
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See the project and researchersNeurobiological correlates of TMS
Project Overview
Noninvasive brain stimulation is gaining acceptance as an alternate therapy for an increasing number of disorders, including major depression, schizophrenia, stroke and Parkinson’s disease. A form of noninvasive brain stimulation called transcranial magnetic stimulation (TMS) is less invasive and safer as compared to other brain stimulation therapies; however, lack of…
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See the project and researchersCanadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial
Project Overview
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for patients with depression who have not responded to antidepressant medications. rTMS involves stimulating the brain with a series of magnetic pulses delivered through a hand-held magnetic coil. Treatment duration is about 40 min and about 8-10 treatments per day can…
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See the project and researchersStimulating Endogenous Regeneration of Photoreceptors as a Potential Cure for Blindness
Project Overview
Sight is the most precious sense, and patients suffering vision loss endure a devastating experience. Blindness often results from the gradual death of photoreceptors, the retinal cells that perceive light. Many researchers are attempting to replace lost cells through transplantation of stem cell-derived photoreceptors. However, integration of injected photoreceptors into…