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676 results found

A unifying approach to treat multisystem proteinopathy and ALS using noninvasive novel ASO delivery

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Multisystem proteinopathy (MSP) is a devastating rare disease described by a cluster of diseases that affect the brain, bone, and muscle. Greater than 50 pathogenic genetic mutations of Valosin-containing protein (VCP) cause MSP. Unfortunately, patients with the mutation, even within the same family, can display any combination of the cluster…

Project Ongoing

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Molecular regulators of extracellular matrix remodeling during Amyotrophic Lateral Sclerosis

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of motor neurons and the atrophy of muscles. Approximately 4,000 Canadians are currently living with ALS, a disease diagnosed in ~1,000 citizens every year and eighty percent of people with ALS die within two to five years…

Project Ongoing

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Imaging Endocannabinoid Signalling in Individuals with Cocaine Addiction

  • Grant Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Cocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Demand for the drug is growing and rates of cocaine use, across age groups, are rising nationwide. Cocaine addiction is a significant public health concern. It is associated with elevated rates of morbidity…

Project Ongoing

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Does the Epstein-Barr virus activate immune cells before multiple sclerosis becomes symptomatic?

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Multiple Sclerosis

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Multiple Sclerosis (MS) is a serious chronic neurological condition, particularly common among young adults in Canada. The exact cause of MS is unknown, but it involves immune cells mistakenly attacking the brain and spinal cord. Symptoms often worsen over time and become chronic, leading to eyesight, movement, mood, and/or memory…

Project Ongoing

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Development of Genetic Screening Platforms for Immune Evasion in Glioblastoma

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

In 2023, over 3,000 Canadians were newly diagnosed as brain tumor, and around 2,500 succumbed to this disease. Despite strenuous efforts to fight against this serious illness, brain tumor is still hard to be cured, and more than half of the patients die within five years of diagnosis. Brain is…

Project Ongoing

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