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Our directory of funded grants

224 result(s) found

Carrier-mediated delivery of therapeutic proteins into the brain

Project Overview

It is estimated that diseases of the brain currently affect over 1.5 billion people worldwide and account for approximately a third of global disease burden. For many neurological diseases, such as Parkinson’s disease, Huntington’s disease, autism and epilepsy, the available treatments are focus…

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Principal Investigator:
  • Roman Melnyk, The Hospital For Sick Children
Team Members:
  • Sheena Josselyn, The Hospital For Sick Children
  • James Ellis, The Hospital For Sick Children
  • Eyal Grunebaum, The Hospital For Sick Children
  • Berge Minassian, The Hospital For Sick Children

CBRAIN: Canadian Brain Research And Informatics Platform

Project Overview

Advances in neuroimaging over the past several years have provided researchers with unprecedented access into the inner workings of the brain. Such data can be collected non-invasively from human subjects so that dynamic changes in brain and behavior can be captured during normal development, aging,…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Faisal Beg, Simon Fraser University
  • Pierre Bellec , Université de Montreal 
  • Louis Collins, McGill University
  • Sultan Darvesh, Dalhousie University
  • Maxime Descoteaux, Université de Sherbrooke
  • Simon Duchesne, Université Laval
  • Jason Lerch, University of Toronto
  • Bruce Pike, Montreal Neurological Hospital and Institute
  • Stephen Strother, Rotman Research Institute
  • Vesna Sossi, University of British Columbia

Centre for Functional and Metabolic Mapping

Project Overview

The Centre for Functional and Metabolic Mapping (CFMM) at Western’s Robarts Research Institute houses Canada’s only collection of high-field (3T human) and ultra-high field (7T human and 9.4T animal) MR systems. The Centre is dedicated to establishing the anatomical, metabolic and functional cha…

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Principal Investigator:
  • Ravi Menon, University of Western Ontario
Team Members:
  • Adrian Owen, University of Western Ontario
  • Stefan Everling, University of Western Ontario
  • Peter Williamson, London Health Sciences Centre
  • Stefan Kohler, University of Western Ontario
  • Rhodri Cusack, University of Western Ontario
  • Robert Bartha, Robarts Research Institute
  • Melvyn Goodale, University of Western Ontario
  • Steven Lomber, University of Western Ontario
  • Daniel Ansari, University of Western Ontario
  • Trevor Birmingham, University of Western Ontario
  • Amer Burhan, London Health Sciences Centre
  • Jorge Burneo, London Health Sciences Centre
  • Mel Boulton, London Health Sciences Centre
  • Michael Borrie, Parkwood Hospital
  • Arthur Brown, University of Western Ontario
  • Craig Campbell, London Health Sciences Centre
  • Dave Cechetto, University of Western Ontario
  • Blaine Chronik, University of Western Ontario
  • Brian Corneil, University of Western Ontario
  • Jody Culham, University of Western Ontario
  • Robert Cumming, University of Western Ontario
  • Sean Cregan, University of Western Ontario
  • Mark Daley, University of Western Ontario
  • Sandrine De Ribaupierre, University of Western Ontario
  • Greg Dekaban, University of Western Ontario
  • Maria Drangova, University of Western Ontario
  • Neil Duggal, University of Western Ontario
  • Aaron Fenster, University of Western Ontario
  • Davinia Fernandez-Espanjo, University of Western Ontario
  • Valter Feyles, University of Western Ontario
  • Elizabeth Finger, University of Western Ontario
  • Sandra Fisman, University of Western Ontario
  • Paul Frewen, University of Western Ontario
  • Al Getgood, University of Western Ontario
  • Karen Gordon, University of Western Ontario
  • Jessica Grahn, University of Western Ontario
  • Paul Gribble, University of Western Ontario
  • Elizabeth Hayden, University of Western Ontario
  • Robert Hegele, University of Western Ontario
  • David Holdsworth, University of Western Ontario
  • Murray Huff, University of Western Ontario
  • Chil Yong Kang, University of Western Ontario
  • Marc Joanisse, University of Western Ontario
  • Mandar Jog, London Health Sciences Centre
  • Ruth Lanius, London Health Sciences Centre
  • Andrew Leask, University of Western Ontario
  • Ting Lee, University of Western Ontario
  • Stan Leung, Western University
  • Ruth Martin, University of Western Ontario
  • Scott MacDougall/Shackleton, University of Western Ontario
  • Donna McBain, London Health Sciences Centre
  • Seyed Mirsattari, London Health Sciences Centre
  • Derek Mitchell, London Health Sciences Centre
  • Robert Nicolson, University of Western Ontario
  • Bruce Morton, Western University
  • JB Orange, University of Western Ontario
  • Tom Overend, University of Western Ontario
  • Terry Peters, University of Western Ontario
  • Marco Prado, University of Western Ontario
  • Raj Rajakumar, University of Western Ontario
  • Susanne Schmid, University of Western Ontario
  • Cheryle Seguin, University of Western Ontario
  • David Sherry, University of Western Ontario
  • Kevin Shoemaker, University of Western Ontario
  • Shiva Singh, University of Western Ontario
  • David Spence, University of Western Ontario
  • Femke Steijger, University of Western Ontario
  • Michael Strong, University of Western Ontario
  • Jean Theberge, St. Joseph's Hospital
  • Jonathan Thiessen, University of Western Ontario
  • Vilis Tutis, University of Western Ontario
  • Akshya Vasudev, University of Western Ontario
  • Tim Wilson, University of Western Ontario
  • Raymond Yee, University of Western Ontario
  • Barbara Fisher, Victoria Hospital, London Health Sciences Centre
  • Paula Foster, University of Western Ontario
  • Keith St. Lawrence, St. Joseph's Hospital
  • Darcy Fehlings, Holland Bloorview Kids Rehabilitation Hospital
  • A. Randy MacIntosh, Rotman Research Institute
  • Donald Welsh, University of Calgary
  • Brian MacVicar, University of British Columbia

Characterization of a novel medulloblastoma tumor suppressor

Project Overview

Medulloblastoma is a pediatric cancer of the brain and is the most common solid tumour in children. Currently, the standard therapy for medulloblastoma remains nonspecific to the cancer subtype and consists of surgery followed by chemotherapy and/or craniospinal irradiation. Due to these treatments,…

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Principal Investigator:
  • Sabrina Schlienger, IRCM

Characterization of MATR3 Mutations Associated with ALS

Project Overview

For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. By creating the first-ever cell, fruit fly a…

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Principal Investigator:
  • Jeehye Park,

    SickKids

Characterization of the role of LRRTMs in synaptic plasticity and memory formation

Project Overview

Dr. Connor’s projects have focused on elucidating the mechanisms governing synapse development, and how synaptic dysfunction is associated with neurologic disorders. Specifically, he has been investigating the role of synaptic adhesion proteins (SAPs), and uncovering the role of these proteins in …

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Principal Investigator:
  • Steven Connor, University of British Columbia

Characterizing the C9ORF72 protein interactome for identifying novel pathogenic pathways in ALS

Project Overview

In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases. Since then, a lot of work has been done to understand how these mutations cause disease…

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Principal Investigator:
  • Janice Robertson, University of Toronto

Co-clinical trials in mice and humans in autism

Project Overview

Autism has many causes, yet no single cause explains why many children and adults have autism. This makes treating the symptoms of autism difficult, since how somebody responds to treatment might depend on what cause autism in the first place. We thus need both better treatments and ways of figuring…

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Principal Investigator:
  • Evdokia Anagnostou,

    Holland Bloorview Kids Rehabilitation Hospital

  • Jason Lerch, University of Toronto
Team Members:
  • Jane Foster, McMaster University
  • Barry Greenberg, Krembil Research Institute
  • Robert Nicolson, University of Western Ontario
  • Teresa Bennett, McMaster University
  • Rosanna Weksberg, The Hospital For Sick Children
  • Stephen Scherer, The Hospital For Sick Children

Co-clinical trials of autism in mice and humans

Project Overview

Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. It is very heterogeneous, with over 250 genes implicated, but is highly heritable. The current therapeutic approach is frequently ineffective partly because often a single treatment is …

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Principal Investigator:
  • Zsuzsa Lindenmaier,

    University of Toronto

Cognitive Outcomes and Response/Remission Efficacy of Convulsive Therapies in Treatment Resistant Depression: The CORRECT-TRD Trial

Project Overview

Magnetic Seizure Therapy (MST) is a novel form of treatment that uses high intensity magnetic field pulses to stimulate the brain and induce a seizure as a therapeutic intervention for patients with depression resistant to antidepressant medication, known as Treatment Resistant Depression (TRD). Pre…

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Principal Investigator:
  • Daniel Blumberger, Centre for Addiction and Mental Health
Team Members:
  • Shawn McClintock, Duke University
  • Kiran Rabheru, University of Ottawa
  • Fidel Vila-Rodriguez, University of British Columbia
  • Zafiris Daskalakis, Centre for Addiction and Mental Health
  • Sarah Lisanby, Duke University
  • Mustafa Husain, Duke University
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto

Combining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?

Project Overview

A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke. This has a tremendous impact on the quality of life and the ability for stroke survivors to live independently. While exercise is considered essential to any rehabilitation program, it…

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Principal Investigator:
  • Marie-Hélène Milot, Université de Sherbrooke
Team Members:
  • François Tremblay, University of Ottawa
  • Marie-Hélène Boudrias, McGill University
  • Hélène Corriveau, Université de Sherbrooke

Correction of Neuronal Function in Autism

Project Overview

The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Altered communication between brain cells may lead to the defects responsible for the features that …

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Principal Investigator:
  • Laurie Doering, McMaster University
Team Members:
  • Min Zhuo, University of Toronto
  • Ali Pejmun Haghighi, McGill University
  • David Nelson, Baylor College of Medicine

Cortical GABAergic interneurons migration impairment in genetic epileptic encephalopathies

Project Overview

This project aims at elucidating the roles of new candidate genes in brain development, particularly in the context of refractory paediatric epilepsies (epileptic encephalopathies) and co-morbid neurodevelopmental disorders such as autism and intellectual deficiency.  Lara Eid is particularly inter…

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Principal Investigator:
  • Lara Eid, CHU-Saint Justine

CRF receptor-mediated sensitization of 5-HT2A receptor signalling

Project Overview

Anxiety and depression often present as co-morbid disorders and the expression and severity of these illnesses is commonly associated with stressful experiences. Both are widespread and serious disorders that affect the lives of 10-15% of Canadians for most of their lifetime. There are multiple pote…

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Principal Investigator:
  • Cornelia Walther, University of Western Ontario

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

Project Overview

In the human brain and retina, the chemical glutamate is a very important messenger that carries information from one neuron to another. The levels of glutamate transmitted between neurons must be tightly controlled: too high and neurons die, too low and information is not communicated properly. In …

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Principal Investigator:
  • Don van Meyel, Research Institute of the McGill University Health Centre
Team Members:
  • Keith Murai, Research Institute of the McGill University Health Centre
  • Adriana Di Polo, CHUM Research Centre, University of Montréal
  • Tim Murphy, University of British Columbia

Deciphering eEF2K biological functions for therapeutic targeting of neural tumours

Project Overview

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He h…

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Principal Investigator:
  • Poul Sorensen, University of British Columbia

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

Project Overview

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understoo…

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Principal Investigator:
  • Lisa Topolnik,

    CHUL, Université Laval

Defining conserved functions of RNA binding proteins in stress-granule biogenesis

Project Overview

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Since the discovery of TDP-43 in 2006 as a substance that plays a major role in ALS, the hypothesis that abnormal regulation of RNA is criti…

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Principal Investigator:
  • Eric Lecuyer, Institut de Recherches Cliniques de Montréal, Université de Montréal