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Our directory of funded grants

335 result(s) found

Biomarkers for Crossing the Translational Divide in Acute Spinal Cord Injury

Project Overview

Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Unfortunately, none of the promising treatments that have emerged from animal models of SCI have d…

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Principal Investigator:
  • Brian Kwon, University of British Columbia
Team Members:
  • Robert Balshaw, University of British Columbia
  • Leonard Foster, University of British Columbia
  • Christoph Borchers, University of Victoria
  • Kendall Jensen, Translational Genomics Research Institute
  • Liang Li, University of Alberta
  • Guohui Lin, University of Alberta
  • Corey Nislow, University of British Columbia
  • Vanessa Noonan, Rick Hansen Institute
  • Bruce McManus, University of British Columbia

BIOTIC: The BIOmedical Translational Imaging Centre

Project Overview

Moving neuroscience research from the lab and turning it into a product is extremely challenging. Even the most groundbreaking technologies may never improve a patient’s life if the commercialization path is not successfully navigated. For small Canadian start-up companies with a great neurotechno…

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Principal Investigator:
  • Steven Beyea, IWK Health Centre
Team Members:
  • Tim Bardouille, IWK Health Centre
  • Chris Bowen, IWK Health Centre
  • Kim Brewer, QEII Health Sciences Centre, Dalhousie University
  • Steve Patterson, IWK Health Centre
  • Lauren Petley, IWK Health Centre
  • James Rioux, QEII Health Sciences Centre, Dalhousie University

Brain channelopathies: target validation and novel therapeutic strategies

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretio…

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Principal Investigator:
  • Terry Snutch, University of British Columbia
Team Members:
  • Brian MacVicar, University of British Columbia
  • Yu Tian Wang, University of British Columbia
  • Pieter Cullis, University of British Columbia
  • John Howland, University of Saskatchewan

Brain pericyte calcium signaling during vasomotion and neurovascular coupling

Project Overview

The brain requires a large amount of energy and oxygen for survival. In order to meet these requirements, the blood supply to the brain is tightly controlled to ensure that active areas receive more blood. Recently, cells known as pericytes, which are found on small blood vessels, were shown to play…

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Principal Investigator:
  • Jillian Stobart, University of Manitoba

Brain Tumour Registry of Canada

Project Overview

The proposed initiative will make every brain tumour count! We will enhance the Canadian Cancer Registry (CCR) and brain tumour research capacity by providing data on an additional 40% of primary brain tumours diagnosed between 2010 and 2014 to the neurooncology community for the first time. The rat…

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Principal Investigator:
  • Faith Davis, University of Alberta
Team Members:
  • Jacob Easaw, University of Calgary
  • Marshall Pitz, University of Manitoba
  • Joseph Megyesi, University of Western Ontario
  • Yutaka Yasui, University of Alberta
  • Yan Yuan, University of Alberta
  • Mary McBride, BC Cancer Agency
  • Wilson Roa, University of Alberta
  • Thierry Muanza, McGill University
  • Claire Infante-Rivard, McGill University
  • Marie-Christine Guiot, Montreal Neurological Hospital and Institute

Brain-Computer Interface Integrated Augmentative and Alternative Communication

Project Overview

This projects looks at a new method to interface with communication devices through brain activity. A brain interface provides access for individuals with brain injury, or who are not typically developing, who experience limited voluntary muscle control.  Kaela Shea will investigate the possibilit…

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Principal Investigator:
  • Kaela Shea, Holland Bloorview

Brain, Mind and Consciousness

Project Overview

The Azrieli Program in Brain, Mind & Consciousness brings together 22 researchers to examine what consciousness is and how it comes about. The program is part of the Canadian Institute for Advanced Research, which was founded in 1982 to bring together researchers from across disciplines and borders …

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Principal Investigator:
  • Adrian Owen, University of Western Ontario
  • Melvyn Goodale, University of Western Ontario
Team Members:
  • Tim Bayne, University of Western Ontario
  • Axel Cleeremans, Université libre de Bruxelles
  • Dehaene Stanislas, Inserm
  • Sheena Josselyn, The Hospital For Sick Children
  • Lisa Saksida, University of Cambridge
  • Laurel Trainor, McMaster University
  • Robert Zatorre, McGill University

Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivo

Project Overview

Recording the electrical impulses of neurons with optical methods in the brain will be enormously beneficial for understanding how the healthy brain functions, as well as how diseases of the brain impact its normal function. In this project, the team will develop methods to record electrical activit…

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Principal Investigator:
  • Katalin Toth, Université Laval

Building the Rick Hansen Alberta Spinal Cord Injury Registry

Project Overview

There are an estimated 86,000 people living with a spinal cord injury (SCI) in Canada, with an annual economic burden of $2.67 billion for those surviving the initial injury. Approximately half of SCIs are the result of a traumatic (T) incident (ex. motor vehicle accident, sports injury) and the oth…

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Principal Investigator:
  • Chester Ho, University of Calgary
Team Members:
  • Monica Gorassini, University of Alberta
  • Vivian Mushahwar, University of Alberta
  • Vanessa Noonan, Rick Hansen Institute
  • Andrew Nataraj, University of Alberta
  • Brad Jacobs, University of Calgary
  • Dalton Wolfe, Lawson Health Research Institute
  • Luc Noreau, Université Laval
  • Patrick Whelan, University of Calgary

Canadian Open Neuroscience Platform (CONP)

Project Overview

The Canadian Open Neuroscience Platform (CONP) is a national platform for open sharing of neuroscience research data and brings together many of the country’s leading scientists in basic and clinical neuroscience to form an interactive network of collaborations in brain research, interdisciplinary…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Stephen Strother, Rotman Research Institute
  • Stephen Scherer, The Hospital For Sick Children
  • Yoshua Bengio, Université de Montréal
  • Jon Stoessl, University of British Columbia
  • James Kennedy, Centre for Addiction and Mental Health
  • Simon Duchesne, Université Laval
  • Glenda MacQueen, Hotchkiss Brain Institute, University of Calgary
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • Ingrid Johnsrude, University of Western Ontario
  • Tristan Glatard, Concordia University

Canadian Open Parkinson Network (C-OPN)

Project Overview

The Canadian Open Parkinson Network, or C-OPN, is a national network that unites researchers, physicians and patients across Canada to study Parkinson’s disease (PD). It is an expansion of the Quebec Parkinson Network, which under 4 years has enrolled over 1100 patients and has helped conduct 51 r…

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Principal Investigator:
  • Oury Monchi, University of Calgary
Team Members:
  • Edward Fon, McGill University
  • Jon Stoessl, University of British Columbia
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • David Park, University of Ottawa
  • Martin McKeown, Brain Research Centre, University of British Columbia
  • Antonio Strafella, University Health Network
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Richard Camicioli, University of Alberta
  • David Grimes, University of Ottawa

Canadian Optogenetics and Vectorology Foundry

Project Overview

Optogenetics is a relatively new science subdomain that is revolutionizing brain research with great promises for therapeutics. Oxford dictionary defines it as a technique in neuroscience in which genes for light-sensitive proteins are introduced into specific types of brain cells in order to monito…

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Principal Investigator:
  • Yves De Koninck, Université Laval
Team Members:
  • Marie-Eve Paquet, Université Laval
  • Paul De Koninck, Université Laval
  • Robert Campbell, University of Alberta
  • Keith Murai, Research Institute of the McGill University Health Centre
  • Edward Ruthazer, McGill University
  • Stuart Trenholm, McGill University
  • Reza Sharif-Naeini, McGill University
  • Thomas Durcan, Montreal Neurological Institute and Hospital, McGill University
  • Tomoko Ohyama, McGill University
  • Edward Fon, McGill University
  • Jean-Claude Béïque, University of Ottawa
  • Stephanie Borgland, Hotchkiss Brain Institute, University of Calgary
  • Lynn Raymond, University of British Columbia

Canadian Paediatric Stroke Imaging Research Platform: Harnessing an International Focus

Project Overview

Stroke is a leading cause of adult and childhood focal brain injury and disability. Most stroke patients die or face disability (mental or physical), impacting individuals for many decades. Children are 3 times more likely to have normal motor outcomes than adults with similar strokes. However, the …

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Principal Investigator:
  • Nomazulu Dlamini, The Hospital For Sick Children
Team Members:
  • Trish Domi, University of Toronto
  • Andrea Kassner, The Hospital For Sick Children
  • Adam Kirton, Alberta Children's Hospital Research Institute
  • Bruce Bjornson, University of British Columbia
  • Michael Rivkin, Boston Children's Hospital
  • Mubeen Rafay, Winnipeg Children's Hospital
  • Stephen Strother, Rotman Research Institute
  • Steven Miller, The Hospital For Sick Children
  • Gabrielle A. deVeber, Hospital for Sick Children

Canadian Partnership for Stroke Recovery Clinical Trials Platform

Project Overview

The overall goals of the Canadian Partnership for Stroke Recovery Clinical Trials Platform is to create a national network of stroke rehabilitation clinical trial sites, help train future researchers and test potential high impact new recovery approaches. Dr. Bayley and his team will do this…

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Principal Investigator:
  • Mark Bayley, Toronto Rehabilitation Institute
Team Members:
  • Dale Corbett, University of Ottawa
  • Sandra Black, Sunnybrook Health Sciences Centre
  • William McIlroy, University of Waterloo
  • Michelle Ploughman, Memorial University of Newfoundland
  • Sean Dukelow, University of Calgary
  • Janice Eng, University of British Columbia
  • Stephen Strother, Rotman Research Institute
  • Marilyn MacKay-Lyons, Dalhousie University
  • Robert Teasell, Parkwood Institute

Canadian Platform for Research in Non-Invasive Brain Stimulation (CanStim)

Project Overview

More Canadians are surviving stroke today than in previous years, but improved survival also means that more individuals are living with a disability due to stroke. Over 400,000 Canadians have a disability related to stroke. Rehabilitation after stroke is critical for regaining function and reducing…

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Principal Investigator:
  • Alexander Thiel, Jewish General Hospital
Team Members:
  • Jodi Edwards, University of Ottawa Heart Institute
  • Numa Dancause, Université de Montréal
  • Stephen Scott, Queen's University
  • Douglas Cook, Queen's University
  • Lara Boyd, University of British Columbia
  • Sean Dukelow, University of Calgary
  • Catherine Mercier, Université Laval
  • Marc Roig Pull, McGill University
  • Joyce Fung, McGill University
  • Michelle Ploughman, Memorial University of Newfoundland

Canadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial

Project Overview

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for patients with depression who have not responded to antidepressant medications. rTMS involves stimulating the brain with a series of magnetic pulses delivered through a hand-held magnetic coil. Treatment duration is abo…

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Principal Investigator:
  • Zafiris Daskalakis, Centre for Addiction and Mental Health
Team Members:
  • Fidel Vila-Rodriguez, University of British Columbia
  • Aristotle Voineskos, Centre for Addiction and Mental Health
  • Sidney H. Kennedy, University Health Network
  • Raymond Lam, University of British Columbia
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto
  • Daniel Blumberger, Centre for Addiction and Mental Health
  • Tarek Rajji, Centre for Addiction and Mental Health
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Christopher Honey, University of Toronto

Carrier-mediated delivery of therapeutic proteins into the brain

Project Overview

It is estimated that diseases of the brain currently affect over 1.5 billion people worldwide and account for approximately a third of global disease burden. For many neurological diseases, such as Parkinson’s disease, Huntington’s disease, autism and epilepsy, the available treatments are focus…

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Principal Investigator:
  • Roman Melnyk, The Hospital For Sick Children
Team Members:
  • Sheena Josselyn, The Hospital For Sick Children
  • James Ellis, The Hospital For Sick Children
  • Eyal Grunebaum, The Hospital For Sick Children
  • Berge Minassian, The Hospital For Sick Children

Causal tests of the hippocampal circuits mediating neural and behavioral pattern completion

Project Overview

Most people have experienced the recollection of a vivid memory after encountering a trigger, such as a familiar place, object, or smell. In neuroscience, this process is called ‘pattern completion’. For years people have thought that a particular part of the brain, called the ‘trisynaptic cir…

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Principal Investigator:
  • Mark Brandon,

    Douglas Hospital Research Centre

CBRAIN: Canadian Brain Research And Informatics Platform

Project Overview

Advances in neuroimaging over the past several years have provided researchers with unprecedented access into the inner workings of the brain. Such data can be collected non-invasively from human subjects so that dynamic changes in brain and behavior can be captured during normal development, aging,…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Faisal Beg, Simon Fraser University
  • Pierre Bellec , Université de Montreal 
  • Louis Collins, McGill University
  • Sultan Darvesh, Dalhousie University
  • Maxime Descoteaux, Université de Sherbrooke
  • Simon Duchesne, Université Laval
  • Jason Lerch, University of Toronto
  • Bruce Pike, Montreal Neurological Hospital and Institute
  • Stephen Strother, Rotman Research Institute
  • Vesna Sossi, University of British Columbia