Directory of funded grants

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552 results found

Quantitative PET/MR Imaging of Brain Derived Neurotrophic Factor (BDNF) / Tropomyosin Related Kinase B (TRKB) signaling in ALS – decoding a potential pathogenetic pathway

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition, BDNF/TrkB signaling can be triggered via activation of adenosine 2A receptors (A2aRs), which in turn transactivates TrkB. Evidence suggests that alterations in BDNF/TrkB can…

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Investigating the neuronal function of a novel HNRNPA1 variant

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt amyotrophic lateral sclerosis (ALS) progression has remained elusive. This is due in part to our incomplete understanding of the molecular mechanisms that lead to disease and a lack of validated biomarkers to…

Project Ongoing

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AID-ME: Artificial Intelligence in Depression – Medication Enhancement: A Randomized, Patient and Rater Blinded, Active-Controlled Trial of a DeepLearning Enabled Clinical Decision Aid for Personalized Depression Treatment Selection

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $390,000

  • Health Canada Contribution

    $195,000

Project Overview

We are testing a new digital mental health solution for physicians to better manage the treatment of depression. While many treatment options for depression are available, individual responses to treatment vary tremendously. Almost 70% of patients will not recover after their first treatment attempt, forcing them to undergo an often…

Project Ongoing

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BEAM: Building Emotional Awareness and Mental Health in Parenting. An appbased intervention to improve postpartum mental health and support children’s brain development

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $950,000

  • Health Canada Contribution

    $475,000

Project Overview

Postpartum mental health problems, including depression and anxiety, affect 15-20% of people and are a serious public health concern. Untreated postpartum mental health problems can be long-lasting, and lead to behaviour problems, brain changes, and risk for later mental illness in children. Rates of postpartum depression and anxiety are very…

Project Ongoing

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Optimization of Prefrontal Theta-Burst Stimulation to Treat Depression: A Bench to First-in-Human Study

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $950,000

  • Health Canada Contribution

    $475,000

Project Overview

Major depression is among the most common and most burdensome human diseases worldwide. While there are several existing treatments, overall current treatments are modest in their efficacy. Over the past few decades, there has been significant development in the field of Transcranial Magnetic Stimulation (TMS) to treat depression. TMS protocols…

Project Ongoing

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