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587 results found

Evaluating the histone variant macroH2A1.1 as a master regulator of PARP1-Sirt1 balance in Alzheimer’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $50,000

Project Overview

Alzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. These markers are influenced by PARP1, which propagates cellular damage, and Sirt1, which protects against cellular damage. PARP1 becomes hyperactive in AD and inhibits Sirt1, thus propagating neuronal damage and memory decline.…

Project Ongoing

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Assessing the Efficacy of a Hypomethylating Agent to Decrease Post-Pneumonia Cognitive Impairments

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $99,999

  • Health Canada Contribution

    $49,999

Project Overview

Infections like pneumonia can speed up dementia. Vaccinations can prevent infections but don’t always work in older adults. We need new drugs to keep aging brains healthy after infections. We found that after mice recover from pneumonia they experience something like dementia. When we gave them a drug called 5’-AZA…

Project Ongoing

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Boosting self-cueing to maintain independence in dementia

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $99,991

  • Health Canada Contribution

    $51,026

Project Overview

Everyday activities such as cooking often become difficult for people living with dementia. We have found that they can still do the physical bits, such as filling a kettle or peeling a potato. The problem is with the cognitive ‘glue’ that sticks the physical steps together. Research has shown that…

Project Ongoing

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The role of TMEM106B in Alzheimer’s disease pathophysiology

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Alzheimer's disease is a common form of memory loss and confusion affecting older adults. Despite many years of study, we still don't have a cure for this disease. Researchers have found that certain genes might play a role, but we are still trying to understand how these genes actually cause…

Project Ongoing

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A critical examination of family caregivers’ views on and experiences with medical assistance in dying

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $78,846

  • Health Canada Contribution

    $39,423

Project Overview

Individuals with an incurable condition marked by decline and intolerable suffering and where death is reasonably foreseeable, as with dementia, now have access to medical assistance in dying (MAID). Family caregivers ofpersons living with dementia support MAID but the reasons for this support are poorly understood. This study aims to…

Project Ongoing

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