Directory of funded grants

Filter by

661 results found

Loss of C9orf72 disrupts nucleoporins and contributes to TDP-43 mislocalization

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $250,000

  • Health Canada Contribution

    $125,000

Project Overview

Subcellular compartmentalization between the nucleus and cytoplasm is primarily governed by two systems; 1) active nucleocytoplasmic transport (NCT) regulated by Ran-GTPase and involving nuclear transport receptors such as Importin β-1, and 2) macromolecular nuclear pore complexes (NPCs), comprised of >30 nucleoporin (Nups) embedded in the nuclear envelope. FG-Nups, the largest…

Project Ongoing

See the project and researchers

Rational targeting of FUS and TDP-43 protein assemblies for diagnostics and treatment of ALS

  • Grant Type

    Team grants

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Alberta

  • Start Date

    2023

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

The project addresses a grand challenge in ALS, the integration of a multi-targeted and personalized approach to patients with a rational strategy focusing on a unifying pivotal mechanism of the disease. We seek to test the extended “prion hypothesis”, which suggests that ALS progression is driven by a self-propagating buildup…

Project Ongoing

See the project and researchers

Elucidating the basis for ubiquitination of misfolded ALS proteins by E3 ligase Enzymes

  • Grant Type

    Team grants

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

A pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub). This observation, also common to Parkinson’s disease, indicates impairment in the ubiquitin-proteasome system that…

Project Ongoing

See the project and researchers

Neuromuscular proteins as potential biomarkers in ALS

  • Grant Type

    Team grants

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $300,000

  • Health Canada Contribution

    $150,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs). Symptoms include muscle paralysis which rapidly progresses and ultimately results in respiratory failure within 2-5 years after diagnosis. Even if several genes causing ALS have been identified, still up to ~90%…

Project Ongoing

See the project and researchers

Axonal degeneration as a therapeutic target for ALS

  • Grant Type

    Team grants

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $300,000

  • Health Canada Contribution

    $150,000

Project Overview

One of the neuron’s most impressive morphological features is their long axonal projections, which are the basis of the complex, precise, and fast-firing neuronal network. To protect these fragile structures, neurons possess mechanisms to actively regulate axonal survival and degeneration, that are independent of the programmed cell death of the…

Project Ongoing

See the project and researchers