Directory of funded grants

Establishing protein signatures of MRI-detected vascular brain injury in circulating endothelial-derived extracellularvesicles in Alzheimer’s disease

Project Overview

Age-related dementias are reaching epidemic levels, affecting over 600,000 Canadians. The most common cause of age-related dementia is Alzheimer’s disease (AD). The defining pathology of AD is the build-up of abnormal forms of two proteins in the brain, amyloid and tau. The majority of people with a diagnosis of AD,…

Investigating a putative modifier of HTT toxicity using cellular assays

Computationally Driven Design and Biochemical Characterization of Improved APT1 Inhibitors as Therapeutics for the Treatment of Huntington Disease

Understanding the interactions between hypertension and HD

Brain pericyte calcium signaling during vasomotion and neurovascular coupling

Project Overview

The brain requires a large amount of energy and oxygen for survival. In order to meet these requirements, the blood supply to the brain is tightly controlled to ensure that active areas receive more blood. Recently, cells known as pericytes, which are found on small blood vessels, were shown to…