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Investigating the role of microglia in brain disorders, by high-throughput single-cell screening of disease-associated genes in human immuno-competent brain avatars

  • Program Type

    Capacity building grants

  • Area of research

    Multiple

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Most brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem acquired over time, as observed in Alzheimer’s disease. Population studies have now pointed to hundreds of DNA variants as possible culprits in these disorders and have highlighted the role of immunity. The functional…

Somatic mutations causing focal epilepsy identified using purified neuronal nuclei from stereo-EEG electrodes

  • Program Type

    Capacity building grants

  • Area of research

    Seizure

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $99,822

  • Health Canada Contribution

    $49,911

Project Overview

Patients with epilepsy have recurrent seizures that lead to injuries, social issues, job and driving restrictions and even death. The cause of epilepsy is often unknown but recent studies have suggested that genetic changes in brain cells that are not inherited but occur during fetal development can cause epilepsy. As…

Somatic mutations causing focal epilepsy identified using purified neuronal nuclei from stereo-EEG electrodes

  • Program Type

    Capacity building grants

  • Area of research

    Seizure

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $99,822

  • Health Canada Contribution

    $49,911

Project Overview

Patients with epilepsy have recurrent seizures that lead to injuries, social issues, job and driving restrictions and even death. The cause of epilepsy is often unknown but recent studies have suggested that genetic changes in brain cells that are not inherited but occur during fetal development can cause epilepsy. As…

Defining the role of primary cilia in shaping astrocyte development and response to brain insults

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. It is increasingly recognized that astrocyte dysfunction is a leading cause of almost all major neurological disorders. These findings have stimulated excitements that astrocyte-based transplant cell therapy and drug…

Defining the role of primary cilia in shaping astrocyte development and response to brain insults

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. It is increasingly recognized that astrocyte dysfunction is a leading cause of almost all major neurological disorders. These findings have stimulated excitements that astrocyte-based transplant cell therapy and drug…