740 results found
Targeting neuronal maturation to promote axon regeneration following spinal cord injury
Project Overview
Spinal cord injury leads to permanent and severe paralysis and loss of sensation. The principal reason for this is that nerve cells connecting the brain with the rest of the body lose the capacity to regenerate their processes (axons) as they mature during development. Despite decades of progress, no regenerative…
Project Ongoing
See the project and researchersSubcortical brain-computer interface to restore motor control after a cortical lesion
Project Overview
Brain-Computer Interfaces (BCIs) are new neurotechnology tools that let our brains communicate directly with external devices in real-time. Their main application is to help people with paralysis control electronic devices like a computer, or even their own paralyzed muscles. The area of the brain mostly used for BCI studies is…
Project Ongoing
See the project and researchersBrain development in moderate to late preterm infants – exploring the relationship between perinatal inflammatory marker profiles and brain development disruptions
Project Overview
Each year, 12.6 million babies worldwide are born when the pregnancy is between 32-36 weeks. This is too early and called moderate-late preterm (MLPT). MLPT babies are more likely to have problems with development and behavior than term-born babies. However, MLPT babies are mostly seen as healthy babies and not…
Project Ongoing
See the project and researchersUnderstand mTOR hyperactivation during cellular interactions using a single-cell approach
Project Overview
The human brain is vulnerable to too much of mTOR signaling, An important neuronal pathway regulating neuronal development and activity. We study TSC, a neurodevelopmental disorder in which patients inherit a germline heterozygous mutation in genes regulating the mTOR pathway and commonly, a second somatic mutation causing mTOR hyperactivation in…
Project Ongoing
See the project and researchersDecoding the Spatial Architecture of Newborn Brain Injury
Project Overview
Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Preterm brain injury is complex, but a major contributor to abnormal brain development is chronic exposure to low oxygen (hypoxia) due to lung immaturity. We…