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676 results found

Characterizing the effects of blocking TDP-43 SUMOylation during cellular stress and recovery using live-cell imaging

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called "SUMOylation" that helps prevent the clumping of TDP-43. We created a mouse model where we disrupted SUMOylation and observed that these…

Project Ongoing

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A combined in-vivo ex-vivo approach to investigate imaging biomarkers in ALS diagnosis and aetiology

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death. While it is known that patients with ALS experience changes in certain brain regions visible on imaging, the relationships between these imaging markers and the underlying mechanisms of…

Project Ongoing

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Role of the gut microbiome-brain axis in sexual dimorphism of ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Alberta

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. However, the mechanisms underlying the sex differences in disease are poorly understood (https://www.nature.com/articles/s41582-024-00991-7). My project aims to investigate the brain-body mechanisms underlying sexual dimorphism in ALS. Specifically, I…

Project Ongoing

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Investigating the role of TDP-43 in DNA Replication: Implications for ALS Pathogenesis

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

Cells are constantly under stress due to several environmental and internal factors. Accumulating stress over a period as seen in aging and neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS) puts additional pressure on the cell's coping machinery. In ALS, neurons and glial cells exhibit altered cellular processes and many proteins…

Project Ongoing

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Investigating cerebellar pathology in a zebrafish C9orf72 ALS model

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. We are particularly interested in a specific gene called C9ORF72, which is found to be mutated in most of the ALS cases.…

Project Ongoing

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