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552 results found

Novel mechanisms regulating intraneuronal Tau clearance as potential targets for Alzheimer’s disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $223,407

  • Health Canada Contribution

    $111,702

Project Overview

In Alzheimer's disease (AD), the accumulation of toxic Tau protein in neurons leads to the formation of neurofbillary tangles, cell death, and cognitive impairments. The precise regulation of Tau levels in neurons is therefore essential to the survival of neurons, and defects in these mechanisms likely play a central part…

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Role of mitochondrial c-Src kinase in Alzheimer’s disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants

  • Province

    New Brunswick

  • Start Date

    2016

  • Total Grant Amount

    $225,000

  • Health Canada Contribution

    $112,500

Project Overview

Mitochondrial dysfunctions are observed before and during the progression of Alzheimer's disease (AD). It is important to understand how the regulation of mitochondria is impaired in AD. The c-Src kinase has appeared as an important regulator of mitochondria. The aim of this research program is to explore, for the first…

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Tracking Alzheimer’s disease progression at the earliest stages: a multimodal project

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $225,000

  • Health Canada Contribution

    $112,500

Project Overview

New neuroimaging techniques enable us to measure the key hallmarks of Alzheimer's disease (AD) pathology before symptoms appear. The AD pathologic process is known to begin decades before the appearance of dementia symptoms such as memory or language deficits. Therefore, Dr. Villeneuve will use these new imaging methods alongside existing…

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The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $224,040

  • Health Canada Contribution

    $112,020

Project Overview

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Enhancers are elements in the DNA code that enable the complex expression of genes. Epigenetic marks control enhancers, which in turn creates specific…

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Novel Cellular and Molecular Mechanisms Regulating Synapse Dysfunction in Alzheimer’s Disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $224,952

  • Health Canada Contribution

    $112,476

Project Overview

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment called AΠ that disrupt synapse function and cause neuronal death. Dr. Kennedy and his team will study a protein called netrin-1 that promotes cell…

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