Project Overview

Stroke is a leading cause of adult and childhood focal brain injury and disability. Most stroke patients die or face disability (mental or physical), impacting individuals for many decades. Children are 3 times more likely to have normal motor outcomes than adults with similar strokes. However, the burden of lifelong disability from motor and emergent non-motor sequelae of injury remain poorly understood. Since the developing brain has an enhanced capacity for recovery, pediatric stroke provides a unique model for studying mechanisms of focal brain injury and repair. Imaging is a crucial next step in advancing this understanding. The Platform will harness investigator talents across Canada and internationally to study mechanisms of brain injury and, more importantly, brain recovery after stroke. Elucidating mechanisms of plasticity/rewiring will inform the development of more effective mechanism-specific treatment approaches including neuroprotective and rehabilitation strategies to reduce stroke-related death and disability. This could benefit stroke patients at all ages. A coordinated multi-site approach, achievable by a funded Platform will accelerate this goal. Other forms of acquired focal brain injury (traumatic, neoplastic, infection) could also potentially benefit from rehabilitation treatments developed in this process. Combined sharing of adult stroke and pediatric stroke data-sets and analysis pipelines will be the future of the Platform, thereby synergizing our understanding of stroke recovery mechanisms across the human lifespan.

Principal Investigator

Nomazulu Dlamini , The Hospital For Sick Children

Team Members

Trish Domi, University of Toronto

Andrea Kassner, The Hospital For Sick Children

Adam Kirton, Alberta Children’s Hospital Research Institute

Bruce Bjornson, University of British Columbia

Michael Rivkin, Boston Children’s Hospital

Mubeen Rafay, Winnipeg Children’s Hospital

Stephen Strother, Rotman Research Institute

Steven Miller, The Hospital For Sick Children

Gabrielle A. deVeber, Hospital for Sick Children

Partners and Donors

The Hospital for Sick Children Foundation