Closed-loop deep brain stimulation using chronic intracranial cortical sensing to inform subcortical stimulation delivery
Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to stop walking unexpectedly and makes them more likely to fall. Conventional deep brain stimulation (DBS) has been used to treat FoG, but hasn’t been very effective. A new form of DBS, called “closed-loop” DBS, would continuously monitor brain activity and only deliver stimulation when it detects unhealthy activity that causes FoG. This study aims to investigate the best way to use this new form of DBS by studying biomarkers of FoG, testing different stimulation patterns, and combining this knowledge to deliver the most effective stimulation.
Luka Milosevic , University Health Network
Partners and Donors
The Azrieli Foundation