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Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

Project Overview

The team wants to take a new breakthrough technology called Cyto-iGluSnFR (pronounced “sight-oh-eye-glue-sniffer”) and adapt it for the discovery of drugs to treat a variety of brain and eye diseases. Cyto-iGluSnFR is an engineered protein that senses the chemical glutamate, allowing scientists to see and measure the rate by which glutamate enters cells. Glutamate is a very important messenger that carries information from one neuron to another, but the levels of glutamate between them must be tightly controlled: too high and neurons die, too low and information is not communicated properly. In either case this can contribute to neurological diseases including stroke, glaucoma, and Alzheimer’s. Glutamate levels are controlled by glial cells found next to neurons, and they do this my taking up glutamate through one of two types of transporter proteins on their surface called EAATs. The EAATs are very attractive targets for the development of new drug therapies, but until now the tools available have made it difficult to make significant progress. The invention of the Cyto-iGluSnFR glutamate biosensor completely changes this bleak outlook, and with this funding we plan to adapt it to enable millions of chemicals to be screened in order to find drugs that make EAATs either more or less effective at moving glutamate into glial cells. These potential drugs can then be further tested using the very same biosensor in fruit flies and mice – important research models where neurons and glial cells function as they do in humans – in order to make sure they are safe and effective for patients. By adapting Cyto-iGluSnFR for multiple stages of drug development and testing, our team of experts will build a comprehensive platform to accelerate progress toward new therapies for brain and eye diseases.

Principal Investigator

Don van Meyel , Research Institute of the McGill University Health Centre

Team Members

Keith Murai, Research Institute of the McGill University Health Centre

Adriana Di Polo, CHUM Research Centre, University of Montréal

Tim Murphy, University of British Columbia

Partners and Donors

CQDM

Ontario Brain Institute

Project Complete

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

  • Grant Type

    Platform grants

  • Area of research

    Neurotechnology

  • Competition

    CQDM - Brain Canada - Focus on Brain

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $1,416,375

  • Health Canada Contribution

    $597,292

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Please note all online donations will receive an electronic tax receipt, issued by Brain Canada Foundation.

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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  • About
    • What We Do
    • EDI Action Plan
    • Leadership
    • Team
    • Annual Report
    • Publications
    • Careers
  • Brain Conditions
    • One Brain
    • ALS
    • Autism (ASD)
    • Brain Cancer
    • Brain Injury
    • Dementia
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • More
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
    • Research Impact Stories
    • Equity, Diversity and Inclusion
    • Brain Health in Indigenous Communities
    • Women’s Brain Health
    • Mind Over Matter
  • How You Can Help
    • Ways to Give
    • Start a Fundraiser
    • Workplace Giving
    • The Great Minds
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