Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

Project Overview

In the human brain and retina, the chemical glutamate is a very important messenger that carries information from one neuron to another. The levels of glutamate transmitted between neurons must be tightly controlled: too high and neurons die, too low and information is not communicated properly. In either case this can contribute to neurological diseases including stroke, glaucoma, and Alzheimer’s. Glutamate levels are controlled by glial cells found next to neurons, and they do this by taking up glutamate through one of two types of transporter proteins on their surface called EAATs. The EAATs are very attractive targets for the development of new drug therapies. However, compounds that modify EAAT function have been difficult to identify due to a lack of available tools. Cyto-iGluSnFR (pronounced “sight-oh-eye-glue-sniffer”) is a new breakthrough technology that the team intends to adapt for the discovery of EAAT-based drugs to treat a variety of brain and eye diseases. Cyto-iGluSnFR is an engineered protein that senses glutamate, allowing scientists to see and measure the rate by which glutamate enters cells. With this funding the team plans to adapt this Cyto-iGluSnFR glutamate biosensor in order to enable millions of chemicals to be screened in order to find drugs that make EAATs either more or less effective at moving glutamate into glial cells. These potential drugs can then be further tested using the very same biosensor in laboratory mice – where neurons and glial cells function as they do in humans – in order to make sure they are safe and effective for patients.  The Cyto-iGluSnFR platform is likely to have impact at each of the following main steps in the drug discovery process: Target identification, Discovery/Screening, Lead optimization, and Preclinical Testing. By adapting Cyto-iGluSnFR for multiple stages of drug development and testing, our team of experts will build a comprehensive platform to accelerate progress toward new therapies for brain and eye diseases.

Content from CQDM: https://www.cqdm.org/en/projects-portfolio/project/45

Principal Investigator

Don van Meyel , Research Institute of the McGill University Health Centre

Team Members

Keith Murai, Research Institute of the McGill University Health Centre

Adriana Di Polo, CHUM Research Centre, University of Montréal

Tim Murphy, University of British Columbia

Partners and Donors

CQDM

Ontario Brain Institute

Project Ongoing

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

  • Program Type

    Platform grants

  • Area of research

    Neurotechnology

  • Competition

    CQDM - Brain Canada - Focus on Brain

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $1,416,375

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co