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Funded Grants

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Defining the role of primary cilia in shaping astrocyte development and response to brain insults

Project Overview

Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. It is increasingly recognized that astrocyte dysfunction is a leading cause of almost all major neurological disorders. These findings have stimulated excitements that astrocyte-based transplant cell therapy and drug discovery are emerging as promising therapeutic strategies for neurological disorders. However, to develop safe and effective treatments, there is an urgent need to address major gaps in our knowledge: How do astrocytes respond to the changes within their microenvironment in distinct physiological conditions? How do genetic and environmental factors induce astrocyte dysfunction? We recently made a novel discovery that astrocytes with defective primary cilia, small signaling antenna on astrocytes that detect external signals, show changes in shape, gene expression, and responses to invasive brain injury. Taking advantage of our unique ciliary experimental toolkit, in vivo live imaging, and single-cell RNAseq, we will test our hypothesis:

Hypothesis: Primary Cilia convey critical environmental signals to astrocytes to modulate astrocyte development and reactivation to brain insults.

Specifically, our goals are:
1. To define how ciliary activity modulates astrocytic activity in development and stab wound injury.
2. To define how primary cilia guide astrocyte differentiation and reaction to brain injury.

Principal Investigator

Jiami Guo , University of Calgary

Partners and Donors

Azrieli Foundation

Project Ongoing

Defining the role of primary cilia in shaping astrocyte development and response to brain insults

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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