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Dopaminergic modulation of stroke recovery

Project Overview

Strokes often cause brain damage that affects normal cognitive and sensorimotor functions. The brain has the extraordinary ability to adapt by forming new circuits which can, to some extent, compensate for neuronal loss. The recovery of motor function can be improved by rehabilitation exercises aimed at strengthening the brain and spinal cord motor circuits. However, stroke recovery is often slow and incomplete.

Dopaminergic neurons of the midbrain are often associated to pleasure and rewards. These neurons normally release a burst of dopamine in order to indicate that ‘something good’ just happened, a signal which drives changes throughout the brain, reinforcing previously active circuits to increase the likelihood that this ‘something good’ reoccurs.

We hypothesize that dopaminergic signals have a strong potential to drive changes in the brain and spinal cord motor circuits and that they can be leveraged to improve motor recovery after stroke. We propose an experiment in laboratory rats to test whether the stimulation of dopamine neurons during rehabilitation exercises can enhance brain repair. To achieve this, we will train rats to a knob rotation task known to sensitively measure fine forelimb motor function. After subjecting rats to a controlled stroke, stimulation of dopamine neurons will be applied immediately after motor actions which are incrementally better than average. This may activate the natural signal controlling the brain adaptation and reinforce useful motor circuits responsible for that action.

We expect that this precisely timed dopaminergic stimulation will greatly accelerate and improve motor recovery beyond what is possible with physical training alone. In addition to motor function, we will examine whether stimulation of dopamine neurons increased the number of descending motor connections between the brain and the muscles. Our results will provide a novel understanding of the role of dopamine in brain repair and have direct implications for rehabilitation.

Principal Investigator

Christian Ethier , Université Laval

Partners and Donors

The Azrieli Foundation

Project Complete

Dopaminergic modulation of stroke recovery

  • Grant Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Please note all online donations will receive an electronic tax receipt, issued by Brain Canada Foundation.

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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Registration number: 89105 2094 RR0001

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  • About
    • What We Do
    • EDI Action Plan
    • Leadership
    • Team
    • Annual Report
    • Publications
    • Careers
  • Brain Conditions
    • One Brain
    • ALS
    • Autism (ASD)
    • Brain Cancer
    • Brain Injury
    • Dementia
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • More
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
    • Research Impact Stories
    • Equity, Diversity and Inclusion
    • Brain Health in Indigenous Communities
    • Women’s Brain Health
    • Mind Over Matter
  • How You Can Help
    • Ways to Give
    • Start a Fundraiser
    • Workplace Giving
    • The Great Minds
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