Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism
This project is focused on role of the integrated stress response (ISR) pathway in fragile X syndrome as well as autism. Mehdi Hooshmandi is aiming to figure out the exact ISR pathway abnormalities in different cell types and regions of the brain. Once the altered molecule(s) is identified, it will be possible to manipulate the pathway pharmacologically. Moreover, this may lead to a potential biomarker for early diagnosis of neurodevelopmental diseases including fragile X syndrome and autism.
Mehdi Hooshmandi , McGill University
Partners and Donors