Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Project Overview

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most children with life-long motor impairments, and in many cases the effects of rehabilitation are minimal. One potential mechanism for further enhancing the effects of therapy is to combine treatment with non-invasive brain stimulation, such as Transcranial Magnetic Stimulation (TMS), which can modulate the excitability of target brain regions, however, the feasibility of this approach is difficult to assess clinically, as the location and size of the injury varies significantly across subjects. Our approach will be to employ a mouse model of perinatal stroke to evaluate the efficacy of two forms interventions that may improve function: 1) Tactile stimulation of the impaired limb during development; 2) Paired Associative Stimulation (PAS) of the injured hemisphere in adulthood. We will injure the motor cortex in 7 day old pups through photothrombosis, and assess hand function through a fully automated skilled reaching paradigm that animals can perform within the home-cage. To evaluate the effects of our interventions on the cortical control of movement we will perform optogenetic motor mapping across both the intact and injured hemispheres.

Principal Investigator

Greg Silasi , University of Ottawa

Project Ongoing

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co