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Funded Grants

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Evaluation of Long-Axis Hippocampal Subfield Volumetry as a neuroimaging biomarker for Alzheimer’s disease

Project Overview

The hippocampus is the brain region which shows the most severe changes in patients with Alzheimer’s disease. Magnetic resonance imaging can be used to measure these changes in order to improve diagnosis and evaluate potential treatment options for patients with Alzheimer’s disease.

The hippocampus is not a uniform brain region, but displays differences in both structure and function comparing its front to back portions. However, methods have not yet been developed to measure changes throughout the hippocampus in patients with Alzheimer’s disease. Our study will use cadaver brain samples to develop a new method which is capable of evaluating the entire hippocampus in patients with Alzheimer’s disease. We will then evaluate whether our measurements can accurately measure the pathology of this condition. Finally, we will determine whether measurements made with our technique can identify which specific patients with early Alzheimer’s disease will worsen over time. We believe our study could have a major impact on Alzheimer’s disease, as it will result in a new tool to measure the brain region most severely affected in this condition. This will be extremely helpful for clinical trials aimed at evaluating promising new treatments for this condition.

Principal Investigator

Trevor Steve , University of Alberta

Project Ongoing

Evaluation of Long-Axis Hippocampal Subfield Volumetry as a neuroimaging biomarker for Alzheimer’s disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2021

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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