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Funded Grants

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Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs

Project Overview

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease.  Dr. Gros and team previously  uncovered genes  that  can  prevent  neuroinflammation  and provide new opportunities for drug discovery for a variety of clinical indications. Here, they propose to specifically inhibit the ubiquitin-specific protease 15 (USP15), in view of managing and treating neuroinflammation. This project  will  expand the therapeutic  field  for  USP15,  map  out  USP15  pathways   and  associated  partners  in  immune  cells,  better  understand the  functional  role  of  USP15  in  brain  and  in immune  cells  during  neuroinflammation and pursue the development and validation of small molecule USP15 inhibitors.  The whole project   will   build   value   through   identification   of small   molecule   leads   for   modulating   USP15   for   neuroinflammation and bring it closer to the clinic.

Principal Investigator

Philippe Gros , McGill University

Partners and Donors

CQDM

McGill University (HBHL)

Project Ongoing

Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs

  • Program Type

    Platform grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    CQDM - Brain Canada - SynergiQc

  • Province

    Québec

  • Start Date

    2019

  • Total Grant Amount

    $1,375,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

+1 (514) 989-2989 info@braincanada.ca

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