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Immunotherapy as a targeted low-impact treatment of paediatric brain cancers

Project Overview

The existing treatment regimens for children with ependymomas are generally not successful and if successful survivors are left with considerable disabilities including severely diminished IQ, focal neurological and language deficits, and endocrine deficiencies. Dr. Donovan’s current proposal aims to develop an improved targeted therapy, which will increase survival rates, and minimize the tragic effects of the existing non-specific cytotoxic therapies on Canadian children. The overall goal is to use a milder, less toxic therapeutic approach to reduce the immediate and long-term effects of paediatric brain cancer on the developing brain. Dr. Donovan’s research will test the hypothesis that patients who have ERBB2-expressing tumours may respond to ERBB2-specific chimeric antigen receptor (CAR) T cells therapy.

Principal Investigator

Laura Donovan , The Hospital For Sick Children

Partners and Donors

Hospital for Sick Children

Project Complete

Immunotherapy as a targeted low-impact treatment of paediatric brain cancers

  • Program Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $110,000

  • Health Canada Contribution

    $55,000