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Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging

Project Overview

Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences.  Currently, treatment of childhood stroke is limited to prevention of more strokes.  Dr. Domi’s research uses specialized imaging techniques to study the role of the blood-brain barrier, a mechanism that can cause further injury to the brain caused by the stroke.  Because this cannot yet be studied in children, it was studied in a juvenile rat model of stroke. This research will provide new information about the function of the blood-brain barrier the potential to lead to the testing of treatment options that may be more effective, but cannot be currently used in childhood stroke because the risks are unknown.

Principal Investigator

Trish Domi , University of Toronto

Partners and Donors

Hospital for Sick Children

Project Complete

Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging

  • Grant Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Brain Canada - Kids Brain Health Network Training Awards

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $110,000

  • Health Canada Contribution

    $55,000