Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging
Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences. Currently, treatment of childhood stroke is limited to prevention of more strokes. Dr. Domi’s research uses specialized imaging techniques to study the role of the blood-brain barrier, a mechanism that can cause further injury to the brain caused by the stroke. Because this cannot yet be studied in children, it was studied in a juvenile rat model of stroke. This research will provide new information about the function of the blood-brain barrier the potential to lead to the testing of treatment options that may be more effective, but cannot be currently used in childhood stroke because the risks are unknown.
Trish Domi , University of Toronto
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