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Funded Grants

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Mechanisms of delayed death in stroke

Project Overview

Stroke is a major cause of death and disability. At present, there are no clear and effective therapies to aid the majority of patients who suffer stroke. The goals of the present research are to understand the stroke process and identify targets, which block brain cell death following an ischemic insult. The major objective of the project is to understand how select proteins, the cell cycle related Cdks, are involved in brain cell damage. The objectives are to understand how these proteins act together to cause brain cell death and then to determine how inhibition of these signals might prevent brain damage following stroke. Dr. Park and his team have previously generated new and novel data on how these proteins cause brain cells to signal death following stroke. They believe that by understanding how this occurs, they can develop therapeutic strategies to limit stroke-induced damage. For this project, Dr. Park and his team will explore the role of these proteins by first studying how they function in brain cells grown in a dish. They will then test whether inhibition of these proteins in animals (rodents), which have had a stroke, minimizes brain cell death and improves behaviour. Importantly, by defining a molecular pathway by which this death occurs, they can identify several key potential therapeutic targets from stroke-induced brain damage.

Principal Investigator

David Park , University of Ottawa

Partners and Donors

Heart and Stroke Foundation

Project Complete

Mechanisms of delayed death in stroke

  • Grant Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Heart and Stroke Foundation Grant-in-Aid

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $227,406

  • Health Canada Contribution

    $113,703

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Please note all online donations will receive an electronic tax receipt, issued by Brain Canada Foundation.

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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