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Funded Grants

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Mitochondrial dysfunction and neuronal demise: Insights provided by Parkinson’s disease genes

Project Overview

Converging research efforts have recently identified five genes that are associated with familial Parkinson’s Disease (PD), a condition associated with severe motor dysfunction and loss of dopamine-producing cells in the brain. These genes include α-synuclein, Parkin, DJ-1, Pink1, LRRK2. It is striking that all of them have been linked directly or indirectly with the function of mitochondria, small ubiquitous intracellular organelles found in all cells. A research group, led by Dr. Louis-Eric Trudeau from the Université de Montréal undertook collaborative projects to systematically examine PD genes and their control of mitochondrial function and neuronal physiology and survival.

Principal Investigator

Louis-Eric Trudeau , Université de Montréal

Team Members

Edward Fon, McGill University

David Park, University of Ottawa

Heidi McBride, McGill University

Michael Schlossmacher, University of Ottawa

Yong Rao, Centre for Research in Neuroscience

Project Complete

Mitochondrial dysfunction and neuronal demise: Insights provided by Parkinson’s disease genes

  • Program Type

    Team grants

  • Competition

    Brain Repair Program

  • Province

    Québec

  • Start Date

    2007

  • Total Grant Amount

    $1,500,000

Contact Us

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Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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