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Funded Grants

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Multi-scale analyses of brain connectivity and dynamics in autism spectrum conditions

Project Overview

Autism spectrum disorder (ASD) affects approximately 1 in 70 children and is associated to a considerable burden for affected individuals, their families, and health care at large. As ASD remains not very well understood from a neuroscientific perspective, we currently lack diagnostic and intervention approaches that target potential biological mechanisms. The current project utilizes advanced computational neuroimaging techniques to investigate the connections between different brain areas and to study functional signals in individuals with ASD and typically developing controls. Our project is based on a new dataset that contains neuroimaging measures as well as behavioral and genetic data in hundreds of typically developing children and those with a psychiatric diagnosis like ASD.

We will capitalize on new techniques that can visualize whole-brain connectivity in a low dimensional space, which will give a simplified and accessible description of the spatial distribution of whole-brain network anomalies in autism. Using innovative computational models, we will furthermore predict how these changes in connectivity affect dynamic brain function and interrogate associations to mechanisms at the level of cortical microcircuits. Finally, we will relate our findings to spatial expression patterns of genes, and study how our connectivity findings are affected by genetic factors.

Our work will outline how changes in whole brain connectivity affect ongoing brain dynamics and how these relate to changes at the level of cortical microcircuits. Our study may furthermore identify genetic and gene expression factors that contribute to these whole-brain changes, which could potentially help to identify new treatments and to monitor their effects in future trials.

Principal Investigator

Boris Bernhardt , McGill University

Partners and Donors

Azrieli Foundation

Project Ongoing

Multi-scale analyses of brain connectivity and dynamics in autism spectrum conditions

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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