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Funded Grants

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Novel therapeutic strategies to repair brain abnormalities in psychiatric disorders

Project Overview

Communication between brain cells is essential for normal brain function. Healthy brain cells are controlled through chemical messengers that stimulate or inhibit brain activity. Current theories indicate that psychiatric disorders such as addiction, schizophrenia, autism and mental retardation evolve from an imbalance of these chemical messengers leading to a disruption in the way brain cells are able to communicate with each other.

Drugs currently available for the treatment of psychiatric disorders often target multiple receptors throughout the brain. Although these compounds have therapeutic efficacy in subgroups of patients, negative side effects often develop which limit their use. Accordingly, new Pharmacotherapies, designed to target more specific brain processes implicated in various aspects of psychiatric illness, are urgently needed.

Dr. Wang and his team investigated a novel method for treating these disorders, whereby small peptides can target specific sub-cellular processes that disrupt the balance of chemical messengers and hence the normal communication between brain cells. Dysfunction of the normal communication between brain cells has been linked to psychiatric diseases and this new class of drugs is designed to restore normal function in a highly specific manner that will minimize negative side effects. The team’s initial focus was on developing a therapy for drug addiction, however the principles underlying the action of these new drugs could lead to the development of similar treatments for other neurological and neuropsychiatric illnesses, such as Alzheimer’s disease, autism, mental retardation and schizophrenia.

Principal Investigator

Yu Tian Wang , University of British Columbia

Team Members

Stephen Ferguson, University of Ottawa

Alaa El-Husseini, University of British Columbia

Ridha Joober, McGill University

Anthony G. Phillips, University of British Columbia

Project Complete

Novel therapeutic strategies to repair brain abnormalities in psychiatric disorders

  • Grant Type

    Team grants

  • Competition

    Brain Repair Program

  • Province

    British Columbia

  • Start Date

    2007

  • Total Grant Amount

    $1,500,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Please note all online donations will receive an electronic tax receipt, issued by Brain Canada Foundation.

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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