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Funded Grants

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Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids

Project Overview

Bipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality worldwide, due to suicide and cardiovascular death. BD affects ~3% of the global population and >500,000Canadians. Typically, the disease starts during adolescence and has a life-long course, characterized by extreme states of mania and depression, often associated with psychosis and self-harm. The cause of BD is unclear, with a combination of genetic and environmental factors likely to contribute. Given the complex heritability and symptoms of BD, long term clinical management of many patients remains unsatisfactory. Thus, there is a major unmet need for new clinical treatment strategies and drug options to help these patients. To provide better treatments for this disorder, we propose a personalized medicine approach that will yield a better understanding of its biological basis; a realization that would define biological signatures that could help predict responsiveness to therapy. The best treatment for BD is lithium, which due to its effectiveness as a mood stabilizer allows many patients to regain social and occupational functioning. However, lithium is effective in only 30% of BD patients, and the reason why remains elusive. To address this, we will use induced pluripotent stem cell (iPSC) technology to grow human neurons from patient blood samples. This will allow us to study how lithium acts on brain cells, and examine neuronal structure and function of BD patient neurons, with respect to those from non-BD sufferers. Ultimately, this project aims to improve our understanding of BD disease processes, and learn more about how lithium works in some people and not others. The results may provide a signature with which to predict the efficacy of treatment. This would speed-up treatment choice, accelerate recovery, and reduce years of suffering in many patients, in addition to cutting costs.

Principal Investigator

Austen Milnerwood , McGill University

Team Members

Martin Alda, Dalhousie University

Guy Rouleau, Montreal Neurological Hospital and Institute

Partners and Donors

Bell/Bell Let's Talk

Project Ongoing

Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $950,000

  • Health Canada Contribution

    $475,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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Registration number: 89105 2094 RR0001

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