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Funded Grants

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Remote Ischemic Preconditioning to promote CNS remyelination

Project Overview

In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). MS treatments stop inflammation, but can´t repair the damage already done. Repairing myelin might be an effective treatment in MS, but there are no medications available that do this. Our own bodies have ways of repairing myelin. However, these are not working properly in MS. We want to study a new way to improve myelin repair (remyelination).

Remote ischemic preconditioning (or REIP) is not a medication. It consists of blocking the blood flow of a limb (an arm or leg) for short periods of time (using a blood pressure cuff). These short periods of time without blood flow are not harmful, but they trick the body into thinking that harm may be coming. The body then produces substances that could be helpful in the case of real harm. These substances can travel all the way to the brain and could help with remyelination. REIP can be applied in mice by inflating small blood pressure cuffs in the hind limbs. We have performed REIP in mice and have promising results, but we need more information. We want to treat mice with REIP after we cause lesions in their spinal cord by injecting a chemical (under anesthesia). We will test if REIP can accelerate remyelination and change how nerve cells work.

REIP can protect mice brains against stroke. Although REIP has been tested in people with stroke before, no one has looked at MS/remyelination. This is a novel and exciting way to study remyelination that does not involve drugs or medications. Since REIP is safe and easy to do, even in humans, this study could encourage the development of studies to determine if REIP could be helpful for patients with MS.

Principal Investigator

Carlos Camara Lemarroy , University of Calgary

Partners and Donors

Azrieli Foundation

Project Ongoing

Remote Ischemic Preconditioning to promote CNS remyelination

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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