Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

The Role of Translational Control in Cortical Dysgenesis in Mammalian Brain

Project Overview

Dr. Yang is studying genetic mechanisms that alter brain development at a molecular and cellular level, leading to changes implicated in autism spectrum disorder. He does this by studying messenger RNA translation. Previously, Dr. Yang had focused on the elF4E gene, a regulator of mRNA translation, which is genetically altered in individuals with
autism spectrum disorder. He was able to show that the elF4E gene plays an essential role in maintaining neural precursor cells and controlling neurogenesis during embryonic cortical development. Dr. Yang has successfully extended his work, and found that the 4E-T protein has an important role in forming a complex with elF4E to regulate neurogenesis, through an interacting protein known as Smaug2. These findings provide new insights in the underlying biological mechanism of neural development and autism spectrum disorder. The paper describing this work has been viewed 1558 times by thousands of scientists around the world. Dr. Yang has presented at several local conferences, including the Canadian Association of Neuroscience, and was the recipient of the Institute of Neurosciences, Mental Health and Addiction- Canadian Institutes of Health Research Brain Star Award

Principal Investigator

Guang Yang , The Hospital For Sick Children

Partners and Donors

Bell Canada

Project Ongoing

The Role of Translational Control in Cortical Dysgenesis in Mammalian Brain

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Mental illness

  • Competition

    Bell Mental Health Research Training Awards

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $165,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co