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Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells

Principal Investigator:
  • Katherine Rowland, The Hospital For Sick Children

Project Overview

Dr. Katherine Rowland’s research project explores the dynamic relationship between CSCs and the wider cellular hierarchy in GBM as governed by the canonical Wnt/β-catenin (cWnt) signaling pathway. She aims to address the apparent dichotomy of whether endogenous cWnt signaling functions to promote self-renewal, proliferation or differentiation within the context of the GBM cellular hierarchy. Her work on molecular subgrouping of tumours has the potential to reveal clinically relevant differences between patients.