Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells
Principal Investigator:
- Katherine Rowland, The Hospital For Sick Children
- CIBC
Project Overview
Dr. Katherine Rowland’s research project explores the dynamic relationship between CSCs and the wider cellular hierarchy in GBM as governed by the canonical Wnt/β-catenin (cWnt) signaling pathway. She aims to address the apparent dichotomy of whether endogenous cWnt signaling functions to promote self-renewal, proliferation or differentiation within the context of the GBM cellular hierarchy. Her work on molecular subgrouping of tumours has the potential to reveal clinically relevant differences between patients.