Project Overview

Dr. Katherine Rowland’s research project explores the dynamic relationship between CSCs and the wider cellular hierarchy in GBM as governed by the canonical Wnt/β-catenin (cWnt) signaling pathway. She aims to address the apparent dichotomy of whether endogenous cWnt signaling functions to promote self-renewal, proliferation or differentiation within the context of the GBM cellular hierarchy. Her work on molecular subgrouping of tumours has the potential to reveal clinically relevant differences between patients.