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Funded Grants

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TACKLing the challenges of PREsymptomatic sporadic Dementia – The TACKL-PRED Study

Project Overview

Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major challenge to society, both from a financial and social perspective. Individuals suffering from dementia experience memory loss and decline in other mental abilities, which significantly impacts their quality of life. As a result, their function in society is lost and they become dependent on their family members to provide care to them. The risk for developing dementia is complex, but not yet fully understood. It involves a combination of demographic (age, sex, education), genetic (DNA sequence), cardiovascular (high blood pressure, diabetes, high cholesterol, smoking) and lifestyle (lack of exercise) factors that increases risk for dementia. Novel methods of better understanding this complex risk profile and being able to modify it to reduce the occurrence of dementia are urgently needed. The international TACKL-PRED study will leverage ‘big’ data from several Canadian neurodegenerative disease cohorts (Ontario Neurodegenerative Disease Research Initiative [ONDRI], Canadian Consortium on Neurodegeneration in Aging [CCNA], Sunnybrook Dementia Study [SDS] and the Brain Eye Amyloid Memory [BEAM] study), and a population-based aging cohort from the Netherlands, the Rotterdam Study, to disentangle the complexity underlying risk for dementia. Biomarker experts from the University of Gothenburg in Sweden are also part of the team. Analyses will examine how an individual’s genetic, demographic and cardiovascular background may interact to worsen dementia presentation and/or increase risk of developing dementia. Using these personalized/precision medicine approaches, we hope to be able to improve upon the management and prevention of dementia in the future, thus reducing its impact on Canadians.

Principal Investigator

Mario Masellis , Sunnybrook Health Sciences Centre

Team Members

AmanPreet Badhwar, Université de Montréal

Derek Beaton, St. Michael’s Hospital Center for Research Methods and Data

Malcolm Binns, Baycrest Health Sciences

Roger Dixon, University of Alberta

Howard Chertkow, McGill University

Partners and Donors

Women's Brain Health Initiative

Canadian Institutes of Health Research

Project Ongoing

TACKLing the challenges of PREsymptomatic sporadic Dementia – The TACKL-PRED Study

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    EU Joint Programme – Neurodegenerative Disease Research (JPND)

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $320,198

  • Health Canada Contribution

    $160,099

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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