Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas
Project Overview
The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells in cancer, we can understand how they promote tumor progression. In this project, our goal is to modify the activity of a specific population of immune cells, called myeloid cells, which are abundant in high-grade pediatric brain tumors, to determine their involvement in tumor growth. We will also alter the signals that prevent white blood cells from destroying cancer cells. Our preliminary results are promising, and our studies could pave the way for clinical trials using immunotherapy to treat these devastating diseases in patients.
Principal Investigator
Nada Jabado , Institut de recherche du centre universitaire de santé McGill
Partners and Donors
Cancer Research Society