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In utero exposure to glucocorticoids in humans and an animal model: Epigenetic and transcriptional signatures

Principal Investigator:
  • Aya Sasaki, University of Toronto
  • University of Toronto

Project Overview

This project will study blood obtained from babies shortly after birth and in guinea pigs early in life to discover how genes throughout the genome respond to glucocorticoid treatment. This research has important implications for the fundamental understanding of biological responses to glucocorticoid treatment. The team anticipates that this study will ultimately inform clinical practice in Canada, where a majority of women at risk of preterm birth (more than 10% of all pregnancies) are treated with glucocorticoids in pregnancy.