687 results found
Brain Health Resources and Integrated Diversity (BRAID) Hub
Project Overview
The BRAID Hub (Brain health Resources And Integrated Diversity Hub) addresses critical gaps in Canada's dementia care system. Focused on building a skilled workforce, it aims to provide holistic support for older adults at risk of cognitive impairment and living with dementia, prioritizing quality of life and diversity. The National…
Project Ongoing
See the project and researchersDémêler l’altération du système endocannabinoïde dans la SLA : une nouvelle méthode thérapeutique axée sur la jonction neuromusculaire
Project Overview
A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Results from mentor’s lab and others demonstrated that NMJ denervation in ALS is a complex and dynamic process rather than just a manifestation of sudden global…
Project Ongoing
See the project and researchersLinking reduced cell-specific inhibition to abnormal brain activity in chronic stress
Project Overview
Depression is a leading cause of disability, with a large proportion of treatment-resistant patients. Recent studies have implicated reduced brain inhibition in human depression from a specific neuron type (SST), and new pharmacology boosting this reduced inhibition led to antidepressant and pro-cognitive effects in rodents. However, establishing a direct link…
Project Ongoing
See the project and researchersHarnessing mRNA translation to increase the neuroprotective potential of disease-associated microglia in neurodegenerative diseases
Project Overview
Microglia are the brain's immune cells. Research in recent years has revealed their crucial role in preventing the development of neurodegenerative diseases, including Alzheimer's Disease (AD). However, the precise mechanisms by which microglia lose their potency in protecting the brain, enabling the development of AD, are not fully understood. Our…
Project Ongoing
See the project and researchersDeciphering the link between gut bacteria and glymphatics in neurodegeneration
Project Overview
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. The disease is caused by the degeneration of motor neurons that innervate the voluntary muscles, leading to respiratory failure and death within about 3 years from onset. A central feature of ALS is the abnormal…