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4 results found

Investigating mechanisms of altered lipid droplet dynamics in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or treat neurodegenerative diseases because the cause of neurodegeneration is complex and not well understood. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by…

Project Ongoing

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Investigating mechanisms that cause mitochondrial dysfunction and synaptic loss

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement. As such, their loss leads to muscle weakness, paralysis, and eventually death. Unfortunately, there is no cure or treatments for those living with ALS, in part because the cause…

Project Ongoing

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Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $1,727,424

  • Health Canada Contribution

    $863,712

Project Overview

In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help prevent protein misfolding. This mechanism can become…

Project Ongoing

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Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $195,000

  • Health Canada Contribution

    $97,500

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the…

Project Complete

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