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Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the FUS gene, it causes ALS and it is important to consider all ways in which this altered FUS can cause motor neuron degeneration. By focusing on the synapse, Dr. Sephton will carve a niche in the field of ALS research that not only should reveal important information on its effects when the disease is occurring, but will also complement the work being done by others in the cell body. Undoubtedly, the discoveries that are made over the next three years in the Sephton lab will either reveal information that will lead to a better understanding of how ALS occurs or hopefully provide new targets for therapy in an effort to make ALS a treatable, not terminal disease.

Principal Investigator

Chantelle Sephton , Université Laval

Partners and Donors

ALS Society of Canada

Project Complete

Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $195,000

  • Health Canada Contribution

    $97,500