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Therapeutic validation of gene-based strategies aimed at restoring neuronal KCC2 in ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $250,000

Project Overview

An imbalance between excitation and inhibition is one of the earliest detectable features of amyotrophic lateral sclerosis (ALS). In fact, changes in the inhibitory synaptic system appears to be central to this imbalance and the modulation of this system using potassium-chloride co-transporter 2 (KCC2)-enhancing compounds have proven to be an…

Investigating disease progression and survival outcomes in ALS patients using deep learning and deformation based morphometry

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $78,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience brain changes, particularly in motor areas, the relationships between brain-related changes, patient symptom profiles, and…

Profiling Cortical Excitability in ALS Using Threshold Tracking Transcranial Magnetic Stimulation and Multimodal Biomarkers

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $75,000

Project Overview

Rationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological…

Determining the contribution of acute viral infection on the onset and progression of ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $25,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Defective protein translation: a causative pathway in ALS?

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $75,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…