Directory of funded grants

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519 results found

Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation to Impact Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $441,000

  • Health Canada Contribution

    $220,500

Project Overview

Brain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients. It is also associated with a survival advantage compared to irradiation of…

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Advancing biology based therapies for rhabdoid brain tumours

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $1,214,047

  • Health Canada Contribution

    $607,024

Project Overview

Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using chemotherapy alone.…

Project Ongoing

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Synergistic combination of IAP antagonism and immunotherapy to treat brain cancers

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,200,000

  • Health Canada Contribution

    $600,000

Project Overview

Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr Robert Korneluk has found that combining IAP-blocking drugs with immunotherapy can kill cancer cells very effectively. Dr Korneluk will now…

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Deciphering eEF2K biological functions for therapeutic targeting of neural tumours

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $1,250,000

  • Health Canada Contribution

    $625,000

Project Overview

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He…

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Oncolytic rhabdovirus immunotherapy for brain cancer

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $1,016,157

  • Health Canada Contribution

    $508,079

Project Overview

Dr David Stojdl's lab has custom‑built an oncolytic virus biotherapy specifically for the treatment of the devastating brain cancer, glioblastoma multiforme (GBM). Maraba‑LG kills brain cancer cells but leaves normal healthy tissue intact, and is one of the only oncolytic viruses in the world that can be safely injected at…

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