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519 results found

Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2012 MIRI Team Grants

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,425,000

  • Health Canada Contribution

    $712,500

Project Overview

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons). The disease is characterized by systematic paralysis of the muscles of the limbs, speech, swallowing, and respiration, due to the progressive death of motor…

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Non-invasive treatment of pediatric neurological disorders using MR-guided focused ultrasound (MRgFUS)

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke,  Epilepsy

  • Competition

    2012 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2014

  • Total Grant Amount

    $1,329,420

  • Health Canada Contribution

    $664,710

Project Overview

Neuroscientists and engineers at the University of Toronto, Hospital for Sick Children, and University Health Network and Thunder Bay Regional Research Institute have joined together to develop a novel next generation non-invasive treatment technique, MR guided Focused Ultrasound (MRgFUS), for two common and disabling pediatric neurological conditions, stroke and drug…

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Carrier-mediated delivery of therapeutic proteins into the brain

  • Program Type

    Team grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2012 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2014

  • Total Grant Amount

    $1,662,500

  • Health Canada Contribution

    $831,250

Project Overview

It is estimated that diseases of the brain currently affect over 1.5 billion people worldwide and account for approximately a third of global disease burden. For many neurological diseases, such as Parkinson's disease, Huntington's disease, autism and epilepsy, the available treatments are focused on symptom relief, rather than a cure.…

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Brain channelopathies: target validation and novel therapeutic strategies

  • Program Type

    Team grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2012 MIRI Team Grants

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,425,000

  • Health Canada Contribution

    $712,500

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretion and nerve cell communication in the…

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Uncovering the pathological processes underlying neuronal dysfunction and loss in models of Parkinson’s disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Brain Repair Program

  • Province

    Ontario

  • Start Date

    2011

  • Total Grant Amount

    $1,320,000

  • Health Canada Contribution

    $660,000

Project Overview

The aims of the proposal were to examine the mechanism of how dopamine neurons degenerate in Parkinson (PD) animal models. The work was centered on three recessive genes linked to PD: Pink1, DJ-1, and Parkin. Previous work published by the team had indicated that these genes are associated with mitochondrial…

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