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551 results found

The Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $1,231,293

  • Health Canada Contribution

    $615,646

Project Overview

One of the most important questions of biomedical research is “why do we ail as we age?”. This may be in part due to a breakdown of the body’s circadian rhythm - the physiological process that tunes up or down various bodily functions during the 24 hr cycle. Another aspect…

Reshaping Mitochondrial Efficiency and Integrity to Treat Parkinson’s Disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    2015 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. This movement disorder is thought to be due to the loss of a specific population of nerve cells, the dopamine (DA)-containing neurons located in the substantia nigra pars compacta (SNc). The question as to why this…

Novel blood and neuroimaging markers of Alzheimer’s disease and cerebral amyloid angiopathy

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    2015 MIRI Team Grants

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

As our brains age, they become vulnerable to diseases such as Alzheimer’s disease which can cause dementia. Dementia is defined as cognitive (i.e., thinking) problems that interfere with usual daily activities. In the milder stages of dementia, this includes difficulty with shopping, finances, and cooking. As dementia progresses, difficulties with…

Combining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    2015 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $321,303

  • Health Canada Contribution

    $160,651

Project Overview

A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke. This has a tremendous impact on the quality of life and the ability for stroke survivors to live independently. While exercise is considered essential to any rehabilitation program, its benefits are generally…

Montreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants

  • Program Type

    Team grants

  • Area of research

    Multiple

  • Disease Area

    AutismMental illness

  • Competition

    2015 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ. This suggests that many different mechanisms are causing these disorders in patients. This great diversity has hindered…