720 results found
Social determinants of prevalence, health service use, and developmental outcomes of children with Autism Spectrum Disorder: A population-level study
Project Overview
The objectives of Ms. Siddiqua's project are: (1) to examine the association between neighbourhood socioeconomic status (SES) and prevalence of children with autism spectrum disorder (ASD) across jurisdictions; (2) to examine the association between neighbourhood SES and health service use among children with ASD across jurisdictions; (3) to examine the…
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See the project and researchersEarly Brain Development Following Prenatal Exposure to SSRI Antidepressants and Maternal Depression
Project Overview
Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Fetal exposure to maternal antidepressant use is poorly understood, and further, the effects are often left undistinguished from those following exposure to untreated maternal depression. This project has two goals: (1) to determine the effects of antidepressant exposure during pregnancy on the…
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See the project and researchersTesting white matter pathway’s influence on neural communication: A combined structural and functional neuroimaging study
Project Overview
Ms. Decker will test the hypothesis that myelin damage impairs episodic memory by disrupting neural communication between two memory relevant brain regions, namely, the hippocampus and prefrontal cortex. Accordingly, she will examine neural synchrony, (a measure of neural communication), during an associative encoding and retrieval task in pediatric brain tumor…
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See the project and researchersNon-infectious inflammation induced by uric acid during pregnancy and the impact on child neurodevelopment
Project Overview
This project focuses on how inflammation, without an infection, can alter brain development when a baby was exposed during pregnancy. Marie-Eve Brien investigates how this sub-optimal prenatal environment programs the developing brain for neurodevelopmental disorders through inflammation in the placenta.
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See the project and researchersEnhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS
Project Overview
In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help prevent protein misfolding. This mechanism can become…