770 results found
Defining and targeting clonal hematopoiesis as a driver of glioblastoma growth
Project Overview
We discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP. Patients with glioblastoma and CHIP had more aggressive tumours and worse outcomes, and our preliminary studies suggest that people with CHIP are more…
Project Ongoing
See the project and researchersGPNMB CAR-T Cells as a Multi-Pronged Immunotherapeutic Approach for Glioblastoma
Project Overview
Glioblastoma (GBM) is the most common and deadly adult brain cancer. GBM is particularly challenging because it contains many different cell types that help it grow and resist treatment, one of which are immune cells called macrophages. We identified a protein, GPNMB, found on the surface of both cancer cells…
Project Ongoing
See the project and researchersEngaging neural stem cells for enhanced brain regeneration
Project Overview
Neurological disorders affect more than 1 in 3 people, making them a leading cause of illness and disability worldwide. Currently, there are no effective regenerative therapies, capable of halting progression or reversing neurological diseases. The presence of resident neural stem cells in the adult human central nervous system (brain and…
Project Ongoing
See the project and researchersUnravelling the NeuroMetabolic Circuits of Anti-Obesity medications
Project Overview
Decades of research suggest that obesity is a brain disease. The brain regulates appetite, and when key pathways are disrupted, it can lead to excessive weight gain. This contributes to the classification of obesity as a chronic, relapsing disease rather than simply a result of lifestyle choices. Obesity affects millions…
Project Ongoing
See the project and researchersThe Effect of Vagus Nerve Stimulation on the Autonomic Network in Patients with Drug-Resistant Epilepsy
Project Overview
Epilepsy is a common brain disorder that causes repeated seizures and can significantly affect a person’s daily life. One-third of people with epilepsy have drug-resistant epilepsy (DRE), meaning their seizures do not respond to medications to control seizures. For those who cannot have surgery, treatments like Vagus Nerve Stimulation (VNS)…